Abstract
Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT2C receptor antagonists and the discovery of a new class of potent and selective 5-HT2C molecules are reported.
MeSH terms
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Models, Molecular
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology*
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Pyrrolidinones / chemical synthesis*
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Pyrrolidinones / pharmacology*
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Serotonin 5-HT2 Receptor Antagonists*
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Serotonin Antagonists / chemical synthesis*
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Serotonin Antagonists / pharmacology*
Substances
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Pyrroles
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Pyrrolidinones
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Serotonin 5-HT2 Receptor Antagonists
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Serotonin Antagonists